Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
5-tert-Butyl-3-(2-chloro-benzyl)-7-morpholin-4-yl-3H-[1,2,3]triazolo[4,5-d]pyrimidine → 5-tert-Butyl-3-(2-chloro-benzyl)-7-isoxazolidin-2-yl-3H-[1,2,3]triazolo[4,5-d]pyrimidine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 5-tert-Butyl-3-(2-chloro-benzyl)-7-morpholin-4-yl-3H-[1,2,3]triazolo[4,5-d]pyrimidine | HCID 1433953 | — |
| 반응물 | Isoxazolidine hydrochloride | HCID 12304500 | — |
| 반응물 | 5-tert-butyl-7-chloro-3-(2-chlorobenzyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidine | HCID 86683284 | — |
| 생성물 | 5-tert-Butyl-3-(2-chloro-benzyl)-7-isoxazolidin-2-yl-3H-[1,2,3]triazolo[4,5-d]pyrimidine | HCID 71557885 | — |
반응 단계
In analogy to the procedure described for the synthesis of 5-tert-butyl-3-(2-chloro-benzyl)-7-morpholin-4-yl-3H-[1,2,3]triazolo[4,5-d]pyrimidine (example 1, step c), the title compound was prepared from 5-tert-butyl-7-chloro-3-(2-chlorobenzyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidine and isoxazolidine hydrochloride and isolated as white solid (13.1 mg, 74%). MS (m/e): 373.4 (MH+).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08741906B2 |
| 출처 데이터셋 | uspto-grants-2014_06 |
| ORD ID | ord-cc01f73c61624ed1a3d4cea824df386f |
| 출처 메모 | uspto-grants-2014_06 |