2-Bromo-1-(2-pyridinyl)-1-ethanone hydrobromide → HCID 71559272, 화합물

HRID 400916

반응식

HRID 400916 반응식
C(C1N=C(N2CCC(F)(F)C2)C2N=NN(CC)C=2N=1)(C)(C)C.[C:23]([C:27]1[N:28]=[C:29]([N:36]2[CH2:40][CH2:39][C:38]([F:42])([F:41])[CH2:37]2)[C:30]2[N:35]=[N:34][NH:33][C:31]=2[N:32]=1)([CH3:26])([CH3:25])[CH3:24].Br.Br[CH2:45][C:46]([C:48]1[CH:53]=[CH:52][CH:51]=[CH:50][N:49]=1)=[O:47]>>[C:23]([C:27]1[N:28]=[C:29]([N:36]2[CH2:40][CH2:39][C:38]([F:41])([F:42])[CH2:37]2)[C:30]2[N:35]=[N:34][N:33]([CH2:45][C:46]([C:48]3[CH:53]=[CH:52][CH:51]=[CH:50][N:49]=3)=[O:47])[C:31]=2[N:32]=1)([CH3:26])([CH3:24])[CH3:25]

참가 물질

4

반응물 3

HCID 27762312-Bromo-1-(2-pyridinyl)-1-ethanone hydrobromideHCID 715582055-tert-Butyl-7-(3,3-difluoro-pyrrolidin-1-yl)-3-ethyl-3H-[1,2,3]triazolo[4,5-d]pyrimidineHCID 178441789HCID 178441789, 화합물

생성물 1

HCID 71559272HCID 71559272, 화합물

실험 절차

In analogy to the procedure described for the synthesis of 5-tert-butyl-7-(3,3-difluoropyrrolidin-1-yl)-3-ethyl-3H-[1,2,3]triazolo[4,5-d]pyrimidine (example 61), the title compound was prepared from 5-tert-butyl-7-(3,3-difluoropyrrolidin-1-yl)-3H-[1,2,3]triazolo[4,5-d]pyrimidine and 2-bromo-1-(pyridin-2-yl)ethanone hydrobromide and isolated as dark-brown solid. MS (m/e): 402.3 (MH+).

후처리

  1. customisolated as dark-brown solid

출처 및 근거

ORD 기록
ord-744a35e30a1e416abdfb3801bb9d9cd5
출처 데이터셋
uspto-grants-2014_06
특허 번호
US08741906B2

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