참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Ethanol | HCID 702 | — |
| 반응물 | Sulfuric Acid | HCID 1118 | — |
| 반응물 | Sulfuric acid magnesium salt (1:1) | HCID 24083 | — |
| 반응물 | 4-Fluoro-3-nitrobenzoic acid | HCID 67987 | — |
| 반응물 | Sodium Bicarbonate | HCID 516892 | — |
| 생성물 | Ethyl 4-fluoro-3-nitrobenzoate | HCID 21277355 | — |
반응 단계
A solution of 4-fluoro-3-nitrobenzoic acid (Alfa Aesar, 10.0 g, 54 mmol) and concentrated H2SO4 (0.2 ml, 4.1 mmol) in EtOH (200 ml) was refluxed for 40 h. The mixture was cooled to 0° C., solid NaHCO3 and MgSO4 was added, and the suspension was filtered and concentrated in vacuo. The residue was purified by chromatography on silica gel (0→30% EtOAc-hexanes) to yield the title compound as an off-white solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US08524917B2 |
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| 출처 데이터셋 | uspto-grants-2013_09 |
|---|
| ORD ID | ord-c474b033b567489bbfa0e0a712e1b26f |
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| 출처 메모 | uspto-grants-2013_09 |
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