1-(3,5-Dichlorophenyl)-2-phenylethanone → 3'-Chloro-4'-fluoro-2-phenylacetophenone

HRID 401151노트

반응식

HRID 401151 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([C:9](=[O:17])[CH2:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH:5]=[C:6](Cl)[CH:7]=1.BrC1C=CC([F:25])=C(Cl)C=1>>[Cl:1][C:2]1[CH:3]=[C:4]([C:9](=[O:17])[CH2:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH:5]=[CH:6][C:7]=1[F:25]

참가 물질

3

반응물 2

HCID 27581461-(3,5-Dichlorophenyl)-2-phenylethanoneHCID 35430654-Bromo-2-chloro-1-fluorobenzene

생성물 1

HCID 27575653'-Chloro-4'-fluoro-2-phenylacetophenone수율 20%

실험 절차

Prepared following the procedure described in Intermediate 13, starting from 4-bromo-2-chloro-1-fluorobenzene, where the crude product was purified by column chromatography (PE: EtOAc=100:1) to afford Intermediate 17 (110 mg, yield 20.0%).

후처리

  1. customPrepared
  2. customwas purified by column chromatography (PE: EtOAc=100:1)

출처 및 근거

ORD 기록
ord-8c455b26ddc54e7e96a2ea6228ccf995
출처 데이터셋
uspto-grants-2014_06
특허 번호
US08741915B2

반응 노트

불러오는 중…