1,3-Dibromobenzene → 3'-Bromo-2-Phenylacetophenone

HRID 401157노트

반응식

HRID 401157 반응식
F[C:2]1[CH:3]=[C:4]([CH2:9][C:10]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[O:11])[CH:5]=[CH:6][C:7]=1F.[Br:18]C1C=CC=C(Br)C=1>>[Br:18][C:14]1[CH:13]=[C:12]([C:10](=[O:11])[CH2:9][C:4]2[CH:5]=[CH:6][CH:7]=[CH:2][CH:3]=2)[CH:17]=[CH:16][CH:15]=1

참가 물질

3

반응물 2

HCID 79271,3-DibromobenzeneHCID 27583172-(3,4-Difluorophenyl)-1-phenylethanone

생성물 1

HCID 27570933'-Bromo-2-Phenylacetophenone수율 47.7%

실험 절차

Followed the procedure described in Intermediate 12, starting from 1,3-dibromobenzene, where the crude product was purified by column chromatography (PE:EtOAc=100:1) to give the desired 1-(3-bromophenyl)-2-phenylethanone (520 mg, yield 47.7%).

후처리

  1. customwas purified by column chromatography (PE:EtOAc=100:1)

출처 및 근거

ORD 기록
ord-c1928f7962f34a8f9a6d3e98261b013a
출처 데이터셋
uspto-grants-2014_06
특허 번호
US08741915B2

반응 노트

불러오는 중…