Pyridine → N-(2-hydroxy-5-nitrophenyl)butanamide
반응식
[NH2:1][C:2]1[CH:7]=[C:6]([N+:8]([O-:10])=[O:9])[CH:5]=[CH:4][C:3]=1[OH:11].[CH2:12]([C:15](Cl)=[O:16])[CH2:13][CH3:14].N1C=CC=CC=1>C1COCC1.CCOC(C)=O>[OH:11][C:3]1[CH:4]=[CH:5][C:6]([N+:8]([O-:10])=[O:9])=[CH:7][C:2]=1[NH:1][C:15](=[O:16])[CH2:12][CH2:13][CH3:14]참가 물질
6
실험 절차
To a solution of 2-amino-4-nitrophenol (Aldrich, 1.0 g, 6.5 mmol) in THF (25 ml) was added n-PrCOCl (694 mg, 6.5 mmol) and pyridine (2.6 ml, 32.4 mmol). The reaction was refluxed for 5 days, diluted with EtOAc, washed with H2O and brine, dried over Na2SO4, and concentrated in vacuo. The residue was purified by chromatography on silica gel (0→50% EtOAc-hexanes) to yield the title compound as a brown solid.
후처리
- temperatureThe reaction was refluxed for 5 days
- washwashed with H2O and brine
- dry with materialdried over Na2SO4
- concentrationconcentrated in vacuo
- customThe residue was purified by chromatography on silica gel (0→50% EtOAc-hexanes)
출처 및 근거
- ORD 기록
- ord-deba7b892d654a9ba33e0d0fda19e694
- 출처 데이터셋
- uspto-grants-2013_09
- 특허 번호
- US08524917B2
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