Potassium tert-butoxide → 2-Isopropyl-6-nitro-1H-indole

HRID 40119노트

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HRID 40119 반응식
[CH3:1][CH:2]([CH3:20])[C:3]#[C:4][C:5]1[CH:10]=[CH:9][C:8]([N+:11]([O-:13])=[O:12])=[CH:7][C:6]=1[NH:14]C(=O)CCC.CC([O-])(C)C.[K+]>CN1C(=O)CCC1.CCOC(C)=O>[CH:2]([C:3]1[NH:14][C:6]2[C:5]([CH:4]=1)=[CH:10][CH:9]=[C:8]([N+:11]([O-:13])=[O:12])[CH:7]=2)([CH3:20])[CH3:1]

참가 물질

5

반응물 2

HCID 23665647Potassium tert-butoxideHCID 59762443N-(2-(3-Methylbut-1-ynyl)-5-nitrophenyl)butyramide2회

생성물 1

HCID 597623802-Isopropyl-6-nitro-1H-indole

시약·촉매·용매 2

HCID 8857Ethyl Acetate용매HCID 13387N-methyl-2-pyrrolidone용매

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온도
70 °C

실험 절차

To a solution of N-(2-(3-methylbut-1-ynyl)-5-nitrophenyl)butyramide (Compound 119, 900 mg, 3.29 mmol) in NMP (10 ml) was added KOt-Bu (552 mg, 4.94 mmol) and the mixture was stirred at 70° C. for 16 h, cooled to room temperature, diluted with EtOAc, washed with brine, dried over Na2SO4, and concentrated in vacuo. The residue was purified by chromatography on silica gel (0→25% EtOAc-hexanes) to yield the title compound.

후처리

  1. temperaturecooled to room temperature
  2. washwashed with brine
  3. dry with materialdried over Na2SO4
  4. concentrationconcentrated in vacuo
  5. customThe residue was purified by chromatography on silica gel (0→25% EtOAc-hexanes)

출처 및 근거

ORD 기록
ord-9930116e41c24842af7e9236d560efb7
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08524917B2

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