Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
O-Toluidine → 2,2,2'-Trimethylpropionanilide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | O-Toluidine | HCID 7242 | — |
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | Pivaloyl chloride | HCID 62493 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 2,2,2'-Trimethylpropionanilide | HCID 2734005 | 92% |
반응 단계
To a solution of o-tolylamine (21.4 g, 0.20 mol) and Et3N (22.3 g, 0.22 mol) in CH2Cl2 was added 2,2-dimethyl-propionyl chloride (25.3 g, 0.21 mol) at 10° C. The mixture was stirred overnight at room temperature, washed with aq. HCl (5%, 80 mL), saturated NaHCO3 solution and brine, dried over Na2SO4 and concentrated under vacuum to give 2,2-dimethyl-N-o-tolyl-propionamide (35.0 g, 92%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08741925B2 |
| 출처 데이터셋 | uspto-grants-2014_06 |
| ORD ID | ord-a917c539fa5e492682d65117d70ad927 |
| 출처 메모 | uspto-grants-2014_06 |