Bromine → 1-(5-bromo-2,3-dihydro-1H-indol-1-yl)ethan-1-one

HRID 401293

반응식

HRID 401293 반응식
[N:1]1([C:10](=[O:12])[CH3:11])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][CH2:2]1.[Br:13]Br>C(O)(=O)C>[Br:13][C:6]1[CH:5]=[C:4]2[C:9](=[CH:8][CH:7]=1)[N:1]([C:10](=[O:12])[CH3:11])[CH2:2][CH2:3]2

참가 물질

4

반응물 2

HCID 24408BromineHCID 276731-(2,3-Dihydro-1H-indol-1-yl)ethan-1-one

생성물 1

HCID 7218471-(5-bromo-2,3-dihydro-1H-indol-1-yl)ethan-1-one수율 115.7%

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

To a solution of 1-(2,3-dihydro-indol-1-yl)-ethanone (58.0 g, 0.36 mol) in acetic acid (3000 mL) was added Br2 (87.0 g, 0.54 mol) at 10° C. The mixture was stirred at room temperature for 4 h. The precipitate was collected via filtration to give crude 1-(5-bromo-2,3-dihydro-indol-1-yl)-ethanone (100 g, 96%), which was used directly in the next step.

후처리

  1. filtrationThe precipitate was collected via filtration

출처 및 근거

ORD 기록
ord-578f1f7d1b154573944356fb85b1bf51
출처 데이터셋
uspto-grants-2014_06
특허 번호
US08741925B2

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