Nitric Acid → ST51001883

HRID 401351노트

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HRID 401351 반응식
[C:1]([C:5]1[C:6](=[O:16])[C:7](=[O:15])[CH:8]=[C:9]([C:11]([CH3:14])([CH3:13])[CH3:12])[CH:10]=1)([CH3:4])([CH3:3])[CH3:2].[N+:17]([O-])([OH:19])=[O:18].O>C(O)(=O)C>[C:11]([C:9]1[CH:10]=[C:5]([C:1]([CH3:4])([CH3:2])[CH3:3])[C:6](=[O:16])[C:7](=[O:15])[C:8]=1[N+:17]([O-:19])=[O:18])([CH3:14])([CH3:13])[CH3:12]

참가 물질

5

반응물 3

HCID 944Nitric AcidHCID 962WaterHCID 769153,5-Di-tert-butyl-1,2-benzoquinone

생성물 1

HCID 534779ST51001883수율 24%

시약·촉매·용매 1

HCID 176Acetic Acid용매

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온도
60 °C

실험 절차

To a solution of 3,5-di-tert-butylcyclohexa-3,5-diene-1,2-dione (4.20 g, 19.1 mmol) in acetic acid (115 mL) was slowly added HNO3 (15 mL). The mixture was heated at 60° C. for 40 min before it was poured into H2O (50 mL). The mixture was allowed to stand at room temperature for 2 h, then was placed in an ice bath for 1 h. The solid was collected and washed with water to provide 4,6-di-tert-butyl-3-nitrocyclohexa-3,5-diene-1,2-dione (1.2 g, 24%). 1H NMR (400 MHz, DMSO-d6) δ 6.89 (s, 1H), 1.27 (s, 9H), 1.24 (s, 9H).

후처리

  1. waitwas placed in an ice bath for 1 h
  2. customThe solid was collected
  3. washwashed with water

출처 및 근거

ORD 기록
ord-de4f1c2245dd4ede9e26db7f9b192f8a
출처 데이터셋
uspto-grants-2014_06
특허 번호
US08741925B2

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