Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrogen Bromide → 6-Cyclobutoxy-N-(3,4-difluorobenzyl)-2-isopropyl-1-(pyridin-3-ylmethyl)-1H-indole-3-carboxamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrogen Bromide | HCID 260 | — |
| 반응물 | Bromocyclobutane | HCID 78110 | — |
| 반응물 | 3,4-Difluorobenzylamine | HCID 123572 | — |
| 반응물 | 3-(Bromomethyl)pyridine | HCID 245934 | — |
| 반응물 | 2-isopropyl-6-methoxy-1H-indole-3-carbaldehyde | HCID 59762309 | — |
| 생성물 | 6-Cyclobutoxy-N-(3,4-difluorobenzyl)-2-isopropyl-1-(pyridin-3-ylmethyl)-1H-indole-3-carboxamide | HCID 59762358 | — |
반응 단계
The title compound was prepared from 2-isopropyl-6-methoxy-1H-indole-3-carbaldehyde (Compound 137), 3-(bromomethyl)pyridine.HBr, 3,4-difluorobenzylamine, and cyclobutyl bromide by, in order, General Procedure J, General Procedure K, General Procedure C, General Procedure L, and General Procedure N.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08524917B2 |
| 출처 데이터셋 | uspto-grants-2013_09 |
| ORD ID | ord-55f9e6fabcba425ab1c1072f1aee8be9 |
| 출처 메모 | uspto-grants-2013_09 |