Trifluoroacetic acid → Trifluoroacetylpiperazine

HRID 401614

반응식

HRID 401614 반응식
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14](=[O:19])[C:15]([F:18])([F:17])[F:16])[CH2:10][CH2:9]1)=O)(C)(C)C.FC(F)(F)C(O)=O>C(Cl)Cl>[F:18][C:15]([F:16])([F:17])[C:14]([N:11]1[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]1)=[O:19]

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 20294522Tert-butyl 4-(2,2,2-trifluoroacetyl)piperazine-1-carboxylate

생성물 1

HCID 7172020Trifluoroacetylpiperazine

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of compound 1c (15.15 g, 53.69 mmol) in CH2Cl2 (60 mL) was added trifluoroacetic acid (18 mL) at room temperature. The mixture was stirred at room temperature for 18 h. The solvent was removed by evaporation. Ether (100 mL) was added to the residue. The white solid was collected by filtration, washed with ether, and dried under vacuum. The crude compound 1d was used in the next reaction without further purification. MS m/z (M+H+) 183.1.

후처리

  1. customThe solvent was removed by evaporation
  2. additionEther (100 mL) was added to the residue
  3. filtrationThe white solid was collected by filtration
  4. washwashed with ether
  5. customdried under vacuum
  6. customThe crude compound 1d was used in the next reaction without further purification

출처 및 근거

ORD 기록
ord-13a94fe105ab43799c4b132dee85e047
출처 데이터셋
uspto-grants-2014_06
특허 번호
US08741887B2

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