N-(3,4-Difluorobenzyl)-6-isopropoxy-2-isopropyl-1-(oxazol-2-ylmethyl)-1H-indole-3-carboxamide → 2-Isopropyl-6-methoxy-1-((5-methylisoxazol-3-yl)methyl)-1H-indole-3-carboxylic Acid

HRID 40166노트

반응식

HRID 40166 반응식
[CH:1]([C:4]1[N:5]([CH2:17][C:18]2[CH:22]=[C:21]([CH3:23])[O:20][N:19]=2)[C:6]2[C:11]([C:12]=1[CH:13]=[O:14])=[CH:10][CH:9]=[C:8]([O:15][CH3:16])[CH:7]=2)([CH3:3])[CH3:2].FC1C=C(C=CC=1F)CNC(C1C2C(=CC(OC(C)C)=CC=2)N(CC2OC=CN=2)C=1C(C)C)=[O:31]>>[CH:1]([C:4]1[N:5]([CH2:17][C:18]2[CH:22]=[C:21]([CH3:23])[O:20][N:19]=2)[C:6]2[C:11]([C:12]=1[C:13]([OH:31])=[O:14])=[CH:10][CH:9]=[C:8]([O:15][CH3:16])[CH:7]=2)([CH3:3])[CH3:2]

참가 물질

3

반응물 2

HCID 59762366N-(3,4-Difluorobenzyl)-6-isopropoxy-2-isopropyl-1-(oxazol-2-ylmethyl)-1H-indole-3-carboxamideHCID 866216082-Isopropyl-6-methoxy-1-((5-methylisoxazol-3-yl)methyl)-1H-indole-3-carbaldehyde

생성물 1

HCID 692261582-Isopropyl-6-methoxy-1-((5-methylisoxazol-3-yl)methyl)-1H-indole-3-carboxylic Acid

실험 절차

The title compound was prepared from 2-isopropyl-6-methoxy-1-((5-methylisoxazol-3-yl)methyl)-1H-indole-3-carbaldehyde (Compound 213) by General Procedure K.

출처 및 근거

ORD 기록
ord-7d95345af84f4e64950459918d1e4cec
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08524917B2

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