1,1'-Carbonyldiimidazole → HCID 59625974, 화합물

HRID 401709노트

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HRID 401709 반응식
[NH2:1][C:2]1[CH:3]=[C:4]([CH:9]=[CH:10][C:11]=1[NH:12][C:13]1[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=1)[C:5]([O:7][CH3:8])=[O:6].[C:20](N1C=CN=C1)(N1C=CN=C1)=[O:21]>CN(C=O)C>[F:19][C:16]1[CH:17]=[CH:18][C:13]([N:12]2[C:11]3[CH:10]=[CH:9][C:4]([C:5]([O:7][CH3:8])=[O:6])=[CH:3][C:2]=3[NH:1][C:20]2=[O:21])=[CH:14][CH:15]=1

참가 물질

4

반응물 2

HCID 682631,1'-CarbonyldiimidazoleHCID 59625705HCID 59625705, 화합물

생성물 1

HCID 59625974HCID 59625974, 화합물

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

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온도
90 °C

실험 절차

A mixture of 60d (0.20 g, 0.826 mmol) and 1,1′-carbonyldiimidazole (0.535 g, 3.3 mmol) in DMF (8 mL) was heated at 90° C. for 2 h. The solvent was removed and the residue was triturated with water (15 mL). The resulting precipitate was collected by filtration and washed several times with water. The crude product 60i was used in the next reaction without further purification. MS m/z (M+H+) 287.1.

후처리

  1. customThe solvent was removed
  2. customthe residue was triturated with water (15 mL)
  3. filtrationThe resulting precipitate was collected by filtration
  4. washwashed several times with water
  5. customThe crude product 60i was used in the next reaction without further purification

출처 및 근거

ORD 기록
ord-d14602bffac94f30bbe1121d8eb4af3f
출처 데이터셋
uspto-grants-2014_06
특허 번호
US08741887B2

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