참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 1,2-Dichloroethane | HCID 11 | — |
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | 3-Chloro-6-hydrazinopyridazine | HCID 100787 | — |
| 반응물 | HOAt | HCID 181649 | — |
| 반응물 | 2-(7-Methoxyquinolin-4-yloxy)acetic acid | HCID 57691021 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | N'-(6-chloropyridazin-3-yl)-2-(7-methoxyquinolin-4-yloxy)acetohydrazide | HCID 86630262 | — |
반응 단계
A mixture of 1-(6-chloropyridazin-3-yl)hydrazine (0.372 g, 2.57 mmol), 1-hydroxy-7-aza-benzotriazole (0.350 g, 2.57 mmol), EDC (0.641 g, 3.34 mmol), 2-(7-methoxyquinolin-4-yloxy)acetic acid (0.600 g, 2.57 mmol) and diisopropylethylamine (1.34 ml, 7.72 mmol) in DMF (20 mL) was allowed to stir at 50° C. for 2 h. Concentrated. Reconstitued in MeCN (30 mL). Concentrated with cooling. Product crashed out of solution and was isolated by filtration. Used without further purification. (ESI, pos. ion) m/z: 234.1 (M+H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08524900B2 |
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| 출처 데이터셋 | uspto-grants-2013_09 |
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| ORD ID | ord-fc76c502eb6d407db4f6272427ad0b0f |
|---|
| 출처 메모 | uspto-grants-2013_09 |
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