Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Glycolic Acid → (6-Phenyl-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methanol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Glycolic Acid | HCID 757 | — |
| 반응물 | p-Toluenesulfonic acid monohydrate | HCID 521998 | — |
| 반응물 | 3-Hydrazinyl-6-phenylpyridazine | HCID 6409842 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | (6-Phenyl-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methanol | HCID 57812703 | — |
반응 단계
A mixture of 1-(6-phenylpyridazin-3-yl)hydrazine (2.00 g, 10.7 mmol), glycolic acid (0.825 g, 10.8 mmol), p-TsOH.H2O (2.55 g, 13.4 mmol) in PhMe (50 mL) was refluxed for 14 h. PhMe was removed in vacuo. The resulting solids were diluted with water (30 mL). The mixture was brought to pH˜10 with 2N NaOH. The solids were isolated solid by filtration, washed with water and dried under vacuum to give an off white solid which was used without further purification. (ESI, pos. ion) m/z: 227.0 (M+H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08524900B2 |
| 출처 데이터셋 | uspto-grants-2013_09 |
| ORD ID | ord-6989f4bd20934af588a402f67981da7d |
| 출처 메모 | uspto-grants-2013_09 |