1,4-Dioxane hydrochloride → 6-(2-Fluorobenzyl)-1,4-oxazepan-6-ol Hydrochloride

HRID 401784노트

반응식

HRID 401784 반응식
[F:1][C:2]1[CH:23]=[CH:22][CH:21]=[CH:20][C:3]=1[CH2:4][C:5]1([OH:19])[CH2:11][O:10][CH2:9][CH2:8][N:7](C(OC(C)(C)C)=O)[CH2:6]1.[ClH:24].O1CCOCC1>O1CCOCC1>[ClH:24].[F:1][C:2]1[CH:23]=[CH:22][CH:21]=[CH:20][C:3]=1[CH2:4][C:5]1([OH:19])[CH2:11][O:10][CH2:9][CH2:8][NH:7][CH2:6]1

참가 물질

4

반응물 2

HCID 204431481,4-Dioxane hydrochlorideHCID 57731942tert-Butyl 6-(2-fluorobenzyl)-6-hydroxy-1,4-oxazepane-4-carboxylate

생성물 1

HCID 685346716-(2-Fluorobenzyl)-1,4-oxazepan-6-ol Hydrochloride수율 95%

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

tert-Butyl 6-(2-fluorobenzyl)-6-hydroxy-1,4-oxazepane-4-carboxylate (Preparation 45, 38 g, 0.12 mol, 1 eq) was dissolved in dioxane (200 mL), and 4M hydrogen chloride/dioxane (60.4 mL, 0.24 mol, 2 eq) was added. The mixture was stirred for 24 h, evaporated, and coevaporated with ether. The formed precipitate was washed with ether and dried to give title compound (29.8 g, 0.11 mol, 95%).

후처리

  1. customevaporated
  2. washThe formed precipitate was washed with ether
  3. customdried

출처 및 근거

ORD 기록
ord-a8fe73e4a4a64a66ba50205ab1fe4722
출처 데이터셋
uspto-grants-2014_06
특허 번호
US08741934B2

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