5-Bromoisatoic Anhydride → 6-bromoquinazolin-4-ol

HRID 40239노트

반응식

HRID 40239 반응식
[Br:1][C:2]1[CH:13]=[C:6]2[C:7](O[C:10](=O)[NH:11][C:5]2=[CH:4][CH:3]=1)=[O:8].C([O-])(=O)C.C(N)=[NH2+:19]>CC(O)C>[Br:1][C:2]1[CH:13]=[C:6]2[C:5](=[CH:4][CH:3]=1)[N:11]=[CH:10][NH:19][C:7]2=[O:8]

참가 물질

4

반응물 2

HCID 2885615-Bromoisatoic AnhydrideHCID 10285782Iminomethanaminium acetate

생성물 1

HCID 1354449056-bromoquinazolin-4-ol

시약·촉매·용매 1

HCID 3776Isopropanol용매

실험 절차

A solution of 5-bromoisatoic anhydride (5.0 g, 21 mmol) and formamidinium acetate (2.2 g, 21 mmol) in 60 mL of i-PrOH was heated at reflux for 10 hours. The reaction mixture was cooled to rt and the white solid was collected by filtration. The white solid was washed with small amount of i-PrOH and dried in air to give desired product 6-bromoquinazolin-4(3H)-one. MS (ESI, pos. ion) m/z: 224.9 (M+1).

후처리

  1. temperatureat reflux for 10 hours
  2. filtrationthe white solid was collected by filtration
  3. washThe white solid was washed with small amount of i-PrOH
  4. customdried in air

출처 및 근거

ORD 기록
ord-153754fc21ba4e269689d52dcd513510
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08524900B2

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