HCID 178472741, 화합물 → HCID 178525874, 화합물
반응식
C([O:3][C:4](=[O:26])[CH2:5][NH:6][C@H:7]1[CH2:12][CH2:11][C@@H:10]([O:13][C:14]2[CH:15]=[C:16]3[C:21](=[CH:22][C:23]=2[Cl:24])[C:20](=[O:25])[NH:19][CH:18]=[CH:17]3)[CH2:9][CH2:8]1)C>CO>[Cl:24][C:23]1[CH:22]=[C:21]2[C:16]([CH:17]=[CH:18][NH:19][C:20]2=[O:25])=[CH:15][C:14]=1[O:13][C@@H:10]1[CH2:9][CH2:8][C@H:7]([NH:6][CH2:5][C:4]([OH:26])=[O:3])[CH2:12][CH2:11]1참가 물질
3
실험 절차
185 mg of [4-(7-chloro-1-oxo-1,2-dihydro-isoquinolin-6-yloxy)-cis-cyclohexylamino]-acetic acid ethyl ester (23, crude product) were dissolved in 2 ml methanol. After adding 2 ml of 2 N NaCO3-solution, the solution was stirred at room temperature for 1.5 h. The solvent was evaporated in vacuo and the residue was purified by preparative HPLC, which delivers the title compound as trifluoro acetate. Rt=0.91 min (Method B). Detected mass: 351.3 (M+H+).
후처리
- customThe solvent was evaporated in vacuo
- customthe residue was purified by preparative HPLC, which