Dimethylamine → N,N-dimethyl-1-(3-methyl-4-nitrophenyl)methanamine

HRID 402670노트

반응식

HRID 402670 반응식
[CH3:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[N+:10]([O-:12])=[O:11])[CH2:5]Br.[CH3:13][NH:14][CH3:15].C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[CH3:13][N:14]([CH3:15])[CH2:5][C:4]1[CH:7]=[CH:8][C:9]([N+:10]([O-:12])=[O:11])=[C:2]([CH3:1])[CH:3]=1

참가 물질

5

반응물 3

HCID 674DimethylamineHCID 11430Potassium CarbonateHCID 44459783-Methyl-4-nitrobenzyl bromide

생성물 1

HCID 53486119N,N-dimethyl-1-(3-methyl-4-nitrophenyl)methanamine

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

A solution of 3-methyl-4-nitrobenzyl bromide (1.0 g, 4.3 mmol), anhydrous dimethylamine (0.34 mL, 5.1 mmol) and potassium carbonate (1.5 g, 0.011 mol) in N,N-dimethylformamide (4.5 mL) was stirred at 70° C. for 12 h. Cooled to ambient temperature, the reaction mixture was poured into ice water, extracted with ethyl acetate. The organic layer was washed with water and brine, dried over sodium sulfate and concentrated to afford N,N-dimethyl-1-(3-methyl-4-nitrophenyl)methanamine as oil (0.80 g, y. 95%).

후처리

  1. extractionextracted with ethyl acetate
  2. washThe organic layer was washed with water and brine
  3. dry with materialdried over sodium sulfate
  4. concentrationconcentrated

출처 및 근거

ORD 기록
ord-24615e3b449d4f09b1ac4374387dbff1
출처 데이터셋
uspto-grants-2014_06
특허 번호
US08742113B2

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