Potassium Carbonate → 2-[(3-Methyl-4-nitrophenoxy)methyl]pyrimidine

HRID 402691노트

반응식

HRID 402691 반응식
[N+:1]([C:4]1[C:5]([CH3:11])=[CH:6][C:7]([OH:10])=[CH:8][CH:9]=1)([O-:3])=[O:2].Cl.Cl[CH2:14][C:15]1[N:20]=[CH:19][CH:18]=[CH:17][N:16]=1.C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[CH3:11][C:5]1[CH:6]=[C:7]([CH:8]=[CH:9][C:4]=1[N+:1]([O-:3])=[O:2])[O:10][CH2:14][C:15]1[N:20]=[CH:19][CH:18]=[CH:17][N:16]=1

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 174123-Methyl-4-nitrophenolHCID 200256062-(Chloromethyl)pyrimidine hydrochloride

생성물 1

HCID 867083912-[(3-Methyl-4-nitrophenoxy)methyl]pyrimidine

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

A solution of 4-nitro-m-cresol (0.25 g, 1.6 mmol), 2-(chloromethyl)pyrimidine hydrochloride (0.40 g, 2.4 mmol) and potassium carbonate (0.50 g, 4.0 mmol) in N,N-dimethylformamide (6.0 mL) was stirred at 70° C. for 18 h. Cooled to ambient temperature, the reaction mixture was poured into ice water, extracted with ethyl acetate. The organic layer was washed with water and brine, dried over sodium sulfate, filtered and concentrated to afford 2-[(3-methyl-4-nitrophenoxy)methyl]pyrimidine as crude material (0.32 g, y. 81%) as solid.

후처리

  1. extractionextracted with ethyl acetate
  2. washThe organic layer was washed with water and brine
  3. dry with materialdried over sodium sulfate
  4. filtrationfiltered
  5. concentrationconcentrated

출처 및 근거

ORD 기록
ord-c56424a77c214b8ea3f509cf6f206d72
출처 데이터셋
uspto-grants-2014_06
특허 번호
US08742113B2

반응 노트

불러오는 중…