Ammonium Chloride → 2-Methyl-4-(2-pyrimidinylmethoxy)aniline

HRID 402692노트

반응식

HRID 402692 반응식
[CH3:1][C:2]1[CH:3]=[C:4]([CH:13]=[CH:14][C:15]=1[N+:16]([O-])=O)[O:5][CH2:6][C:7]1[N:12]=[CH:11][CH:10]=[CH:9][N:8]=1.[Cl-].[NH4+]>C(O)C.O.[Fe]>[CH3:1][C:2]1[CH:3]=[C:4]([O:5][CH2:6][C:7]2[N:8]=[CH:9][CH:10]=[CH:11][N:12]=2)[CH:13]=[CH:14][C:15]=1[NH2:16]

참가 물질

6

반응물 2

HCID 25517Ammonium ChlorideHCID 867083912-[(3-Methyl-4-nitrophenoxy)methyl]pyrimidine

생성물 1

HCID 626995032-Methyl-4-(2-pyrimidinylmethoxy)aniline수율 99.6%

시약·촉매·용매 3

HCID 23925Iron촉매HCID 702Ethanol용매HCID 962Water용매

실험 절차

To a solution of 2-[(3-methyl-4-nitrophenoxy)methyl]pyrimidine (0.18 g, 0.7 mmol) in ethanol (4.0 mL) and water (1.0 mL), iron (0.40 g, 7.2 mmol) and ammonium chloride (0.020 g, 0.37 mmol) were added. The mixture was refluxed for 1.5 h. Cooled to ambient temperature, the reaction mixture was filtered over Celite to remove unneeded materials and the filtrate was concentrated to afford 2-methyl-4-(2-pyrimidinylmethoxy)aniline (0.15 g, crude material) as solid.

후처리

  1. temperatureThe mixture was refluxed for 1.5 h
  2. filtrationthe reaction mixture was filtered over Celite
  3. customto remove unneeded materials
  4. concentrationthe filtrate was concentrated

출처 및 근거

ORD 기록
ord-40efd4005d31432296f872f2bb583007
출처 데이터셋
uspto-grants-2014_06
특허 번호
US08742113B2

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