Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 40280생성일: 2026년 10월 23일
tert-Butylsulfinamide, (R)-(+)- → (NZ,R)-N-[(4-bromo-2-chlorophenyl)methylidene]-2-methylpropane-2-sulfinamide
https://huagongshe.com/ko/reaction/40280
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | tert-Butylsulfinamide, (R)-(+)- | HCID 10964479 | — |
| 반응물 | 4-Bromo-2-chlorobenzaldehyde | HCID 14109109 | — |
| 촉매 | Copper Sulfate | HCID 24462 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | (NZ,R)-N-[(4-bromo-2-chlorophenyl)methylidene]-2-methylpropane-2-sulfinamide | HCID 57691068 | — |
반응 단계
A suspension of 4-bromo-2-chlorobenzaldehyde (1150 mg, 5240 μmol), (r)-(+)-2-methyl-2-propanesulfinamide (1588 mg, 13100 μmol), copper(ii) sulfate (696.4 μl, 15720 μmol) in DCM (10 mL) was stirred at 37° C. for 78 h. Reaction filtered through Celite, and solid washed repeatedly with DCM. Filtrate concentrated then purified on silica (80 g) eluting product with 0>30% of EtOAc/Hex. MS (ESI pos. ion) m/z: 322/324 (MH+). Calc'd exact mass for C11H13BrClNOS: 321/323.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US08524900B2 |
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| 출처 데이터셋 | uspto-grants-2013_09 |
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| ORD ID | ord-4f79440e739e4ef3b2297af9766d349c |
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| 출처 메모 | uspto-grants-2013_09 |
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