Dimethylformamide → 8-Chloro-4,4-dimethylthiochroman-6-carbaldehyde

HRID 402809노트

반응식

HRID 402809 반응식
Br[C:2]1[CH:3]=[C:4]2[C:9](=[C:10]([Cl:12])[CH:11]=1)[S:8][CH2:7][CH2:6][C:5]2([CH3:14])[CH3:13].[Li]CCCC.CN([CH:23]=[O:24])C>>[Cl:12][C:10]1[CH:11]=[C:2]([CH:23]=[O:24])[CH:3]=[C:4]2[C:9]=1[S:8][CH2:7][CH2:6][C:5]2([CH3:14])[CH3:13]

참가 물질

4

반응물 3

HCID 6228DimethylformamideHCID 667649386-Bromo-8-chloro-4,4-dimethylthiochromanHCID 178418339Butyllithium

생성물 1

HCID 866768178-Chloro-4,4-dimethylthiochroman-6-carbaldehyde

실험 절차

Using essentially the same procedure as Example 5-20, Step 3, 6-bromo-8-chloro-4,4-dimethyl-3,4-dihydro-2H-thiochromene (954 mg, 3.27 mmol), n-BuLi (1.57 mL, 3.93 mmol) and DMF (1.01 mL, 13.1 mmol) afforded the desired product as a pale-yellow oil.

출처 및 근거

ORD 기록
ord-3489dc472502407298b694e9f83c8ba7
출처 데이터셋
uspto-grants-2014_06
특허 번호
US08742110B2

반응 노트

불러오는 중…