Methylphenidate Hydrochloride → Methylphenidate

온도

50 °C

The Methylphenidate Resin Complex was prepared by first dissolving 500 g of methylphenidate HCl in 8 liters of purified water, and then slowly adding 1,306 g of AMBERLITE™ IRP-69 resin with continuous mixing. The dispersion was mixed for 4 hours and upon completion, allowed to settle before decanting the supernatant. The slurring/decanting process was repeated twice with sufficient amounts of purified water. The wet resin complex was then dried in a VWR™ convection oven maintained at 50° C. until moisture content was about 20-30%. EUDRAGIT™ NE-30D of 467 g was then slowly added to the wet resin complex in a Hobart type mixer (Kitchen Aid) to form a uniform mass. The wet mass was then passed through a 10 mesh screen and again dried at 50° C. in a VWR™ convection oven to the moisture content around 4-6%. The dried granules were then milled through a 40 mesh screen using CO-MIL™ brand mill.

1. additionslowly adding 1,306 g of AMBERLITE™
2. additionThe dispersion was mixed for 4 hours and upon completion
3. custombefore decanting the supernatant
4. customThe wet resin complex was then dried in a VWR™ convection oven
5. additionEUDRAGIT™ NE-30D of 467 g was then slowly added to the wet resin complex in a Hobart type mixer (Kitchen Aid)
6. customto form a uniform mass
7. customagain dried at 50° C. in a VWR™ convection oven to the moisture content around 4-6%
8. customThe dried granules were then milled through a 40 mesh screen

ORD 기록

ord-f3c96954aff34f899b192ad4836bed46

출처 데이터셋

uspto-grants-2014_06

DOI

10.6084/m9.figshare.5104873.v1

특허 번호

US08747902B2