Potassium Carbonate → Tert-butyl 2-((3-(4-benzylpiperidin-1-yl)propyl)(2-tert-butoxybenzyl)amino)ethylcarbamate
반응식
[C:1]([O:5]C1C=CC=CC=1CN(CC1C=CC=CN=1)CCCN1CCC(C2C=CC=CC=2)CC1)([CH3:4])([CH3:3])[CH3:2].[CH2:36]([CH:43]1[CH2:48][CH2:47][NH:46][CH2:45][CH2:44]1)[C:37]1[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=1.[C:49]([O:53][C:54]1[CH:74]=[CH:73][CH:72]=[CH:71][C:55]=1[CH2:56][N:57]([CH2:67][CH2:68][CH2:69]Cl)[CH2:58][CH2:59][NH:60][C:61](=[O:66])C(C)(C)C)([CH3:52])([CH3:51])[CH3:50].C([O-])([O-])=O.[K+].[K+]>>[CH2:36]([CH:43]1[CH2:48][CH2:47][N:46]([CH2:69][CH2:68][CH2:67][N:57]([CH2:56][C:55]2[CH:71]=[CH:72][CH:73]=[CH:74][C:54]=2[O:53][C:49]([CH3:50])([CH3:51])[CH3:52])[CH2:58][CH2:59][NH:60][C:61](=[O:66])[O:5][C:1]([CH3:4])([CH3:3])[CH3:2])[CH2:45][CH2:44]1)[C:37]1[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=1참가 물질
반응물 4
생성물 1
실험 절차
The same procedure as described for compound 20 was applied to 4-benzylpiperidine (0.46 g, 2.63 mmol), compound 23 (0.7 g, 1.75 mmol), KI (0.87 g, 5.25 mmol) and K2CO3 (1.21 g, 8.75 mmol). The residue was purified on a silica gel TLC plate that was developed in 5% methanolic NH3 (7 M NH3 in methanol/95% CH2Cl2. The product was isolated as yellow oil (80% yield). 1H NMR (CDCl3) δ 7.373 (d, 1H, Ar), 7.264 (m, 2H, Ar), 7.176 (t, 1H, Ar), 7.137 (d, 2H, Ar), 7.137 (d, 2H, Ar), 7.108 (d, 1H, Ar), 7.021 (dd, 1H, Ar), 6.985 (t, 1H, Ar), 3.577 (s, 2H, —CH2—), 3.167 (d, 2H, —CH2—), 2.892 (d, 2H, —CH2—), 2.524 (d, 2H, —CH2—), 2.498 (t, 2H, —CH2—), 2.453 (t, 2H, —CH2—), 2.290 (t, 2H, —CH2—), 1.839 (t, 2H, —CH2—), 1.657 (m, 2H, —CH2—), 1.618 (d, 2H, —CH2—), 1.517 (m, 1H, —CH—), 1.426 (s, 9H, —C(CH3)3, 1.376 (s, 9H, —C(CH3)3, 1.329 (overlapped m, 4H). Mass Spec.=538.77 (M+H)+.
후처리
- customThe residue was purified on a silica gel TLC plate that
출처 및 근거
- ORD 기록
- ord-e6466a842207460b93b3a12d7894ee7c
- 출처 데이터셋
- uspto-grants-2014_06
- 특허 번호
- US08747810B2
반응 노트
불러오는 중…