Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Bromine → 2-Bromo-1-(quinolin-6-yl)ethanone hydrobromide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Bromine | HCID 24408 | — |
| 반응물 | 1-(Quinolin-6-yl)ethan-1-one | HCID 258559 | — |
| 반응물 | Acetic Acid Mixture with Hydrobromic Acid | HCID 21893785 | — |
| 생성물 | 2-Bromo-1-(quinolin-6-yl)ethanone hydrobromide | HCID 86630274 | 76.3% |
반응 단계
A 250 mL RB flask was charged with 1-(quinolin-6-yl)ethanone (3.82 g, 22.3 mmol) and 30% HBr/AcOH (45.0 ml). Bromine (1.14 ml, 22.1 mmol) was added slowly. This was stirred at room temperature for 4 hours, at which point full conversion to product (with a small amount of dibrominated side product) was observed. The reaction mixture was filtered and the solid was washed with Et2O to give 2-bromo-1-(quinolin-6-yl)ethanone hydrobromide (5.6359 g, 76.3% yield). The compound was used in the next step without further purification.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08524900B2 |
| 출처 데이터셋 | uspto-grants-2013_09 |
| ORD ID | ord-bec1a85677504629888211f7e5002d4e |
| 출처 메모 | uspto-grants-2013_09 |