Dimethylformamide → 3-Fluoro-5-phenyl-benzo[b]thiophene-2-carbonyl chloride

HRID 403296노트

반응식

HRID 403296 반응식
[F:1][C:2]1[C:3]2[CH:13]=[C:12]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[CH:11]=[CH:10][C:4]=2[S:5][C:6]=1[C:7](O)=[O:8].C(Cl)(C([Cl:24])=O)=O.CN(C=O)C>C(Cl)Cl>[F:1][C:2]1[C:3]2[CH:13]=[C:12]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[CH:11]=[CH:10][C:4]=2[S:5][C:6]=1[C:7]([Cl:24])=[O:8]

참가 물질

5

반응물 3

HCID 6228DimethylformamideHCID 65578Oxalyl chlorideHCID 596258253-Fluoro-5-phenyl-benzo[b]thiophene-2-carboxylic acid

생성물 1

HCID 596257253-Fluoro-5-phenyl-benzo[b]thiophene-2-carbonyl chloride

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of compound 13d (136.2 mg, 0.5 mmol) in CH2Cl2 (5 mL) at room temperature was added (COCl)2 (0.064 mL, 0.75 mmol), followed by DMF (0.01 mL, 0.125 mmol). The reaction mixture was stirred at room temperature for 18 h. The reaction mixture was then concentrated to give compound 13e as a light pink powder, which was used in the next reaction without further purification.

후처리

  1. concentrationThe reaction mixture was then concentrated

출처 및 근거

ORD 기록
ord-a0994920e26b416889a4bff7ba927092
출처 데이터셋
uspto-grants-2014_06
특허 번호
US08748417B2

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