Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-Fluoro-2,4,6-trimethylpyridinium Trifluoromethanesulfonate [Fluorinating Reagent] → methyl 3-fluoro-1H-indole-6-carboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-Fluoro-2,4,6-trimethylpyridinium Trifluoromethanesulfonate [Fluorinating Reagent] | HCID 2724575 | — |
| 반응물 | methyl 1H-indole-5-carboxylate | HCID 2737635 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | methyl 3-fluoro-1H-indole-6-carboxylate | HCID 59625843 | — |
반응 단계
A solution of methyl 1H-indole-6-carboxylate 19a (2.0 g, 11.4 mmol) and N-fluoro-2,4,6-trimethylpyridinium triflate (4.3 g, 14.8 mmol) in MeOH (100 mL) was heated at reflux for 18 h. The reaction mixture was concentrated and purified by flash column chromatography (silica gel, 15-20% EtOAc/hexanes) to give compound 21a as an off-white solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08748417B2 |
| 출처 데이터셋 | uspto-grants-2014_06 |
| ORD ID | ord-2fd051ffcbec40acb49b81de1301ba0c |
| 출처 메모 | uspto-grants-2014_06 |