(4-Fluoro-2-methoxyphenyl)boronic acid → 5-(4-Fluoro-2-methoxy-phenyl)-pyridazin-4-ylamine

HRID 403397노트

반응식

HRID 403397 반응식
Cl[C:2]1[C:3]([NH2:8])=[CH:4][N:5]=[N:6][CH:7]=1.[F:9][C:10]1[CH:15]=[CH:14][C:13](B(O)O)=[C:12]([O:19][CH3:20])[CH:11]=1>CCCCCCC.C(OCC)(=O)C.CO>[F:9][C:10]1[CH:15]=[CH:14][C:13]([C:2]2[C:3]([NH2:8])=[CH:4][N:5]=[N:6][CH:7]=2)=[C:12]([O:19][CH3:20])[CH:11]=1

참가 물질

4

반응물 2

HCID 2782672(4-Fluoro-2-methoxyphenyl)boronic acidHCID 130010635-Chloropyridazin-4-amine

생성물 1

HCID 866984845-(4-Fluoro-2-methoxy-phenyl)-pyridazin-4-ylamine

시약·촉매·용매 1

HCID 21266605Heptane ethyl acetate methanol용매

실험 절차

The title compound was prepared in analogy to example 1, intermediate b, from 5-chloro-pyridazin-4-ylamine (CAS RN 53180-92-0) and 4-fluoro-2-methoxyphenylboronic acid (CAS RN 179899-07-1) and using a gradient of n-heptane:ethyl acetate:methanol (100:0:0 to 0:100:0 to 0:50:50) for the chromatographic purification. Light yellow solid (37%). MS (ESI+): m/z=220.089 ([M+H]+).

후처리

  1. customfor the chromatographic purification

출처 및 근거

ORD 기록
ord-61c8ec7455654a7d8882fb91696f3901
출처 데이터셋
uspto-grants-2014_06
특허 번호
US08748434B2

반응 노트

불러오는 중…