Ethanol → (2S,4R)-2-((1R,2S)-1-(ethoxycarbonyl)-2-vinylcyclopropylcarbamoyl)-4-(4-nitrobenzoyloxy)pyrrolidinium chloride

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To a stirring solution of ethanol at 0° C., was added acetyl chloride (5.7 g). The resulting solution was aged for 30 min. (2S,4R)-tert-Butyl 2-((1R,2S)-1-(ethoxycarbonyl)-2-vinylcyclopropylcarbamoyl)-4-(4-nitrobenzoyloxy)pyrrolidine-1-carboxylate (7.5 g) was then added as a solution in EtOAc (30 mL) to the acidic ethanol slurry solution at 10° C. The reaction was allowed to proceed for 1 h at 10° C., warmed to 15° C. for 1 h and then warmed to 20° C. After 16 h, EtOAc (30 mL) was added to the slurry and the resulting slurry was filtered. The cake was rinsed with EtOAc (30 mL) that had been cooled to 0° C. The title compound was placed in a vacuum oven, at 43° C., to remove residual solvent (6.9 g, 100% yield).

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