Water → 2-((2-Chloro-4-nitrophenoxy)methyl)pyridine

HRID 403655

반응식

HRID 403655 반응식
[OH-].[K+].[N:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[CH2:9][OH:10].[Cl:11][C:12]1[CH:13]=[C:14]([N+:19]([O-:21])=[O:20])[CH:15]=[CH:16][C:17]=1F.O>C(#N)C>[Cl:11][C:12]1[CH:13]=[C:14]([N+:19]([O-:21])=[O:20])[CH:15]=[CH:16][C:17]=1[O:10][CH2:9][C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][N:3]=1

참가 물질

6

반응물 4

HCID 962WaterHCID 11474PiconolHCID 14797Potassium HydroxideHCID 676882-Chloro-1-fluoro-4-nitrobenzene

생성물 1

HCID 174694332-((2-Chloro-4-nitrophenoxy)methyl)pyridine수율 69.6%

시약·촉매·용매 1

HCID 6342Acetonitrile용매2회

반응 조건

온도
35 °C

실험 절차

A mixture of potassium hydroxide (20.6 g, 0.15 mol, 0.52 equiv) and 2-pyridylcarbinol (31.08 g, 0.285 mol, 1.00 equiv) in acetonitrile (750 ml) was stirred at 35° C. for 30 minutes. A solution of the 3-chloro-4-fluoronitrobenzene (50 g, 0.29 mol, 1.00 equiv) in acetonitrile (250 ml) was added and the mixture was stirred at 40° C. for 14 hours and then cooled to room temperature. Water (1000 ml) was added and the precipitated solids were filtered and washed with water and dried to give product 52.5 g. MS (ESI) m/z: 265 (M+1).

후처리

  1. stirringthe mixture was stirred at 40° C. for 14 hours
  2. temperaturecooled to room temperature
  3. filtrationthe precipitated solids were filtered
  4. washwashed with water
  5. customdried

출처 및 근거

ORD 기록
ord-d3f649813b384047864f8537d31e75db
출처 데이터셋
uspto-grants-2014_06
특허 번호
US08748453B2

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