Ammonia → 4-(3-Ethynylphenylamino)-7-methoxyquinazolin-6-ol

HRID 403664노트

반응식

HRID 403664 반응식
Cl.C([O:5][C:6]1[CH:7]=[C:8]2[C:13](=[CH:14][C:15]=1[O:16][CH3:17])[N:12]=[CH:11][N:10]=[C:9]2[NH:18][C:19]1[CH:24]=[CH:23][CH:22]=[C:21]([C:25]#[CH:26])[CH:20]=1)(=O)C.N>CO>[C:25]([C:21]1[CH:20]=[C:19]([NH:18][C:9]2[C:8]3[C:13](=[CH:14][C:15]([O:16][CH3:17])=[C:6]([OH:5])[CH:7]=3)[N:12]=[CH:11][N:10]=2)[CH:24]=[CH:23][CH:22]=1)#[CH:26]

참가 물질

4

반응물 2

HCID 222AmmoniaHCID 866599184-(3-Ethynylphenylamino)-7-methoxyquinazolin-6-yl acetate Hydrochloride

생성물 1

HCID 219252124-(3-Ethynylphenylamino)-7-methoxyquinazolin-6-ol수율 72%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A mixture of 4-(3-ethynylphenylamino)-7-methoxyquinazolin-6-yl acetate hydrochloride (10 g, 0.027 mol), methanol (250 ml) and 25% aqueous ammonia (8 ml, 0.106 mol, 3.93 equiv) was stirred at room temperature for 17 hours and then heated to reflux for 1.5 hours. The mixture was cooled and the precipitate was formed and isolated and dried to give 5.66 g product. MS (ESI) m/z: 307 (M+1).

후처리

  1. temperatureheated
  2. temperatureto reflux for 1.5 hours
  3. temperatureThe mixture was cooled
  4. customthe precipitate was formed
  5. customisolated
  6. customdried

출처 및 근거

ORD 기록
ord-2c03765ed6134140a1c048dfeb4a9b7d
출처 데이터셋
uspto-grants-2014_06
특허 번호
US08748453B2

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