Water → N-(3-ethynylphenyl)-7-methoxy-6-(2-methoxyethoxy)quinazolin-4-amine

HRID 403665

반응식

HRID 403665 반응식
[C:1]([C:3]1[CH:4]=[C:5]([NH:9][C:10]2[C:19]3[C:14](=[CH:15][C:16]([O:21][CH3:22])=[C:17]([OH:20])[CH:18]=3)[N:13]=[CH:12][N:11]=2)[CH:6]=[CH:7][CH:8]=1)#[CH:2].CS(O[CH2:28][CH2:29][O:30][CH3:31])(=O)=O.C(=O)([O-])[O-].[Cs+].[Cs+].O>CN(C=O)C>[C:1]([C:3]1[CH:4]=[C:5]([NH:9][C:10]2[C:19]3[C:14](=[CH:15][C:16]([O:21][CH3:22])=[C:17]([O:20][CH2:28][CH2:29][O:30][CH3:31])[CH:18]=3)[N:13]=[CH:12][N:11]=2)[CH:6]=[CH:7][CH:8]=1)#[CH:2]

참가 물질

6

반응물 4

HCID 962WaterHCID 10796Cesium carbonateHCID 1462932-Methoxyethyl methanesulfonateHCID 219252124-(3-Ethynylphenylamino)-7-methoxyquinazolin-6-ol

생성물 1

HCID 86664384N-(3-ethynylphenyl)-7-methoxy-6-(2-methoxyethoxy)quinazolin-4-amine수율 42.9%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

A solution of 4-(3-ethynylphenylamino)-7-methoxyquinazolin-6-ol (2.9 g, 0.01 mol), 2-methoxyethyl methane sulfonate (4.6 g, 0.03 mol, 3 equiv), and cesium carbonate (9.9 g, 0.03 mol, 3 equiv) in DMF (100 ml) was heated to 60° C. for 12 hours. The reaction mixture was cooled to room temperature and poured into cold water, the solid was filtrated and dried to give 1.5 g product. MS (ESI) m/z: 350 (M+1).

후처리

  1. filtrationthe solid was filtrated
  2. customdried

출처 및 근거

ORD 기록
ord-9e6a86edf15d43158a5bd6e3022104ce
출처 데이터셋
uspto-grants-2014_06
특허 번호
US08748453B2

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