3,4-Difluorophenyl isocyanate → (S)-Methyl 2-(6-(4-(3-(3,4-difluorophenyl)ureido)phenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate

HRID 403716

반응식

HRID 403716 반응식
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:16]=[C:15]3[C:11]([CH2:12][N:13]([C@@H:18]([CH:23]([CH3:25])[CH3:24])[C:19]([O:21][CH3:22])=[O:20])[C:14]3=[O:17])=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.[F:26][C:27]1[CH:28]=[C:29]([N:34]=[C:35]=[O:36])[CH:30]=[CH:31][C:32]=1[F:33]>>[F:26][C:27]1[CH:28]=[C:29]([NH:34][C:35](=[O:36])[NH:1][C:2]2[CH:3]=[CH:4][C:5]([C:8]3[CH:16]=[C:15]4[C:11]([CH2:12][N:13]([C@@H:18]([CH:23]([CH3:25])[CH3:24])[C:19]([O:21][CH3:22])=[O:20])[C:14]4=[O:17])=[CH:10][CH:9]=3)=[CH:6][CH:7]=2)[CH:30]=[CH:31][C:32]=1[F:33]

참가 물질

3

반응물 2

HCID 27347083,4-Difluorophenyl isocyanateHCID 131731441(S)-Methyl 2-(6-(4-aminophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate

생성물 1

HCID 123749611(S)-Methyl 2-(6-(4-(3-(3,4-difluorophenyl)ureido)phenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate

실험 절차

The compound of example 31 was prepared analogous to compound of example 7 by reaction of compound of example 6 with 3,4-difluorophenyl isocyanate. The compound of example 31 was used directly without isolation for the preparation of compound of example 32.

출처 및 근거

ORD 기록
ord-e08fb303080b4addbdc3b870c17eaeb2
출처 데이터셋
uspto-grants-2014_06
특허 번호
US08748426B2

연결된 노트

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