2-Fluorophenyl isothiocyanate → (S)-Methyl 2-(6-(4-(3-(2-fluorophenyl)thioureido)phenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate

HRID 403734

반응식

HRID 403734 반응식
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:16]=[C:15]3[C:11]([CH2:12][N:13]([C@@H:18]([CH:23]([CH3:25])[CH3:24])[C:19]([O:21][CH3:22])=[O:20])[C:14]3=[O:17])=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.[F:26][C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=1[N:33]=[C:34]=[S:35]>C1COCC1>[F:26][C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=1[NH:33][C:34](=[S:35])[NH:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:16]=[C:15]3[C:11]([CH2:12][N:13]([C@@H:18]([CH:23]([CH3:25])[CH3:24])[C:19]([O:21][CH3:22])=[O:20])[C:14]3=[O:17])=[CH:10][CH:9]=2)=[CH:6][CH:7]=1

참가 물질

4

반응물 2

HCID 975202-Fluorophenyl isothiocyanateHCID 131731441(S)-Methyl 2-(6-(4-aminophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate

생성물 1

HCID 53303391(S)-Methyl 2-(6-(4-(3-(2-fluorophenyl)thioureido)phenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

The compound of example 6 (0.150, g, 0.000443 mol) was taken in THF (3 mL) and to this solution was added 2-fluorophenyl isothiocyanate (0.074 g, 0.000448 mol). The reaction mixture was stirred at room temperature for 8-10 h. The reaction mixture was concentrated and directly used for next step without isolation.

후처리

  1. concentrationThe reaction mixture was concentrated

출처 및 근거

ORD 기록
ord-19c996b49928480e9f36ca9b1e34df60
출처 데이터셋
uspto-grants-2014_06
특허 번호
US08748426B2

연결된 노트

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