(S)-2-(6-(4-(3-(2-Fluorophenyl)thioureido)phenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoic acid → (S)-2-(6-(4-(3-(3-Chlorophenyl)thioureido)phenyl)-1-oxoisoindolin-2-yl)-3-methyl butanoic acid

HRID 403747노트

반응식

HRID 403747 반응식
F[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[NH:8][C:9](=[S:34])[NH:10][C:11]1[CH:16]=[CH:15][C:14]([C:17]2[CH:25]=[C:24]3[C:20]([CH2:21][N:22]([C@@H:27]([CH:31]([CH3:33])[CH3:32])[C:28]([OH:30])=[O:29])[C:23]3=[O:26])=[CH:19][CH:18]=2)=[CH:13][CH:12]=1.[Cl:35]C1C=CC(NC(=S)NC2C=CC(C3C=C4C(CN([C@@H](C(C)C)C(OC)=O)C4=O)=CC=3)=CC=2)=CC=1>>[Cl:35][C:7]1[CH:2]=[C:3]([NH:8][C:9](=[S:34])[NH:10][C:11]2[CH:16]=[CH:15][C:14]([C:17]3[CH:25]=[C:24]4[C:20]([CH2:21][N:22]([C@@H:27]([CH:31]([CH3:33])[CH3:32])[C:28]([OH:30])=[O:29])[C:23]4=[O:26])=[CH:19][CH:18]=3)=[CH:13][CH:12]=2)[CH:4]=[CH:5][CH:6]=1

참가 물질

3

반응물 2

HCID 87349957(S)-2-(6-(4-(3-(2-Fluorophenyl)thioureido)phenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoic acidHCID 131731454(S)-Methyl 2-(6-(4-(3-(4-chlorophenyl)thioureido)phenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate

생성물 1

HCID 87349718(S)-2-(6-(4-(3-(3-Chlorophenyl)thioureido)phenyl)-1-oxoisoindolin-2-yl)-3-methyl butanoic acid수율 86%

실험 절차

The compound of example 64 was prepared analogous to compound of example 52 by hydrolysis of compound of example 63.

출처 및 근거

ORD 기록
ord-32b921288bf34c28ba5475beef7e1545
출처 데이터셋
uspto-grants-2014_06
특허 번호
US08748426B2

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