(S)-3-Methyl-2-(1-oxo-6-(4-(phenylsulfonamido)phenyl)isoindolin-2-yl)butanoic acid → (S)-2-(6-(4-(3,4-Difluorophenylsulfonamido)phenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoic acid

HRID 403758노트

반응식

HRID 403758 반응식
CC(C)[C@H](N1CC2C(=CC(C3C=CC(NS(C4C=CC=CC=4)(=O)=O)=CC=3)=CC=2)C1=O)C(O)=O.[F:34][C:35]1[CH:36]=[C:37]([S:42]([NH:45][C:46]2[CH:51]=[CH:50][C:49]([C:52]3[CH:60]=[C:59]4[C:55]([CH2:56][N:57]([C@@H:62]([CH:67]([CH3:69])[CH3:68])[C:63]([O:65]C)=[O:64])[C:58]4=[O:61])=[CH:54][CH:53]=3)=[CH:48][CH:47]=2)(=[O:44])=[O:43])[CH:38]=[CH:39][C:40]=1[F:41]>>[F:34][C:35]1[CH:36]=[C:37]([S:42]([NH:45][C:46]2[CH:47]=[CH:48][C:49]([C:52]3[CH:60]=[C:59]4[C:55]([CH2:56][N:57]([C@@H:62]([CH:67]([CH3:69])[CH3:68])[C:63]([OH:65])=[O:64])[C:58]4=[O:61])=[CH:54][CH:53]=3)=[CH:50][CH:51]=2)(=[O:44])=[O:43])[CH:38]=[CH:39][C:40]=1[F:41]

참가 물질

3

반응물 2

HCID 67306729(S)-3-Methyl-2-(1-oxo-6-(4-(phenylsulfonamido)phenyl)isoindolin-2-yl)butanoic acidHCID 131731460(S)-Methyl 2-(6-(4-(3,4-difluorophenylsulfonamido)phenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate

생성물 1

HCID 67306902(S)-2-(6-(4-(3,4-Difluorophenylsulfonamido)phenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoic acid수율 96%

실험 절차

The compound of example 82 was prepared analogous to compound of example 78 by hydrolysis of compound of example 81.

출처 및 근거

ORD 기록
ord-9372de763e794b89af2a1cf12df7db1d
출처 데이터셋
uspto-grants-2014_06
특허 번호
US08748426B2

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