(S)-2-(6-(4-Benzamidophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoic acid → (S)-3-Methyl-2-(1-oxo-6-(4-(4-(trifluoromethyl)benzamido)phenyl)isoindolin-2-yl)butanoic acid

HRID 403774

반응식

HRID 403774 반응식
C(NC1C=CC(C2C=C3C(CN([C@@H](C(C)C)C(O)=O)C3=O)=CC=2)=CC=1)(=O)C1C=CC=CC=1.[CH3:33][CH:34]([CH3:69])[C@H:35]([N:40]1[CH2:48][C:47]2[C:42](=[CH:43][C:44]([C:49]3[CH:54]=[CH:53][C:52]([NH:55][C:56](=[O:67])[C:57]4[CH:62]=[CH:61][C:60]([C:63]([F:66])([F:65])[F:64])=[CH:59][CH:58]=4)=[CH:51][CH:50]=3)=[CH:45][CH:46]=2)[C:41]1=[O:68])[C:36]([O:38]C)=[O:37]>>[CH3:33][CH:34]([CH3:69])[C@H:35]([N:40]1[CH2:48][C:47]2[C:42](=[CH:43][C:44]([C:49]3[CH:50]=[CH:51][C:52]([NH:55][C:56](=[O:67])[C:57]4[CH:62]=[CH:61][C:60]([C:63]([F:66])([F:64])[F:65])=[CH:59][CH:58]=4)=[CH:53][CH:54]=3)=[CH:45][CH:46]=2)[C:41]1=[O:68])[C:36]([OH:38])=[O:37]

참가 물질

3

반응물 2

HCID 53303631(S)-2-(6-(4-Benzamidophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoic acidHCID 131731466(S)-Methyl 3-methyl-2-(1-oxo-6-(4-(4-(trifluoromethyl)benzamido)phenyl)isoindolin-2-yl)butanoate

생성물 1

HCID 67307752(S)-3-Methyl-2-(1-oxo-6-(4-(4-(trifluoromethyl)benzamido)phenyl)isoindolin-2-yl)butanoic acid수율 89%

실험 절차

The compound of example 102 was prepared analogous to compound of example 98 by hydrolysis of compound of example 101.

출처 및 근거

ORD 기록
ord-58e9fc7c67ff4c05835ec5cc89bfa75e
출처 데이터셋
uspto-grants-2014_06
특허 번호
US08748426B2

연결된 노트

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