3,5-Dimethoxybenzoyl chloride → (S)-Methyl 2-(6-(4-(3,5-diethoxybenzamido)phenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate

HRID 403807

반응식

HRID 403807 반응식
[C:1]([NH:9][C:10]1[CH:15]=[CH:14][C:13]([C:16]2[CH:24]=[C:23]3[C:19]([CH2:20][N:21]([C@@H:26]([CH:31]([CH3:33])[CH3:32])[C:27]([O:29][CH3:30])=[O:28])[C:22]3=[O:25])=[CH:18][CH:17]=2)=[CH:12][CH:11]=1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.NC1C=CC(C2C=[C:48]3C(CN([C@@H](C(C)C)C(OC)=O)[C:47]3=[O:50])=CC=2)=CC=1.C[O:60][C:61]1C=C(C=C(OC)[CH:69]=1)C(Cl)=O>>[CH2:47]([O:50][C:6]1[CH:7]=[C:2]([CH:3]=[C:4]([O:60][CH2:61][CH3:69])[CH:5]=1)[C:1]([NH:9][C:10]1[CH:11]=[CH:12][C:13]([C:16]2[CH:24]=[C:23]3[C:19]([CH2:20][N:21]([C@@H:26]([CH:31]([CH3:33])[CH3:32])[C:27]([O:29][CH3:30])=[O:28])[C:22]3=[O:25])=[CH:18][CH:17]=2)=[CH:14][CH:15]=1)=[O:8])[CH3:48]

참가 물질

4

반응물 3

HCID 870033,5-Dimethoxybenzoyl chlorideHCID 123625862(S)-Methyl 2-(6-(4-benzamidophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoateHCID 131731441(S)-Methyl 2-(6-(4-aminophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate

생성물 1

HCID 131731477(S)-Methyl 2-(6-(4-(3,5-diethoxybenzamido)phenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate수율 77%

실험 절차

The compound of example 145 was prepared analogous to compound of example 97 by reaction of compound of example 6 with 3,5-dimethoxy benzoyl chloride.

출처 및 근거

ORD 기록
ord-452368e0ff8b46b38a78903bb5a118c0
출처 데이터셋
uspto-grants-2014_06
특허 번호
US08748426B2

연결된 노트

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