2-Fluoro-3-(trifluoromethyl)benzoyl chloride → (S)-Methyl 2-(6-(4-(2-fluoro-3-(trifluoromethyl)benzamido)phenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate

HRID 403839노트

반응식

HRID 403839 반응식
C(NC1C=CC(C2C=C3C(CN([C@@H](C(C)C)C(OC)=O)C3=O)=CC=2)=CC=1)(=O)C1C=CC=CC=1.[NH2:34][C:35]1[CH:40]=[CH:39][C:38]([C:41]2[CH:49]=[C:48]3[C:44]([CH2:45][N:46]([C@@H:51]([CH:56]([CH3:58])[CH3:57])[C:52]([O:54][CH3:55])=[O:53])[C:47]3=[O:50])=[CH:43][CH:42]=2)=[CH:37][CH:36]=1.[F:59][C:60]1[C:68]([C:69]([F:72])([F:71])[F:70])=[CH:67][CH:66]=[CH:65][C:61]=1[C:62](Cl)=[O:63]>>[F:59][C:60]1[C:68]([C:69]([F:70])([F:71])[F:72])=[CH:67][CH:66]=[CH:65][C:61]=1[C:62]([NH:34][C:35]1[CH:36]=[CH:37][C:38]([C:41]2[CH:49]=[C:48]3[C:44]([CH2:45][N:46]([C@@H:51]([CH:56]([CH3:58])[CH3:57])[C:52]([O:54][CH3:55])=[O:53])[C:47]3=[O:50])=[CH:43][CH:42]=2)=[CH:39][CH:40]=1)=[O:63]

참가 물질

4

반응물 3

HCID 27375592-Fluoro-3-(trifluoromethyl)benzoyl chlorideHCID 123625862(S)-Methyl 2-(6-(4-benzamidophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoateHCID 131731441(S)-Methyl 2-(6-(4-aminophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate

생성물 1

HCID 131731491(S)-Methyl 2-(6-(4-(2-fluoro-3-(trifluoromethyl)benzamido)phenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate수율 32%

실험 절차

The compound of example 193 was prepared analogous to compound of example 97 by reaction of compound of example 6 with 2-fluoro-3-trifluoromethyl benzoyl chloride.

출처 및 근거

ORD 기록
ord-cd196b4af2434452baa0f9cb7c8c956c
출처 데이터셋
uspto-grants-2014_06
특허 번호
US08748426B2

반응 노트

불러오는 중…