2-Fluorophenyl isothiocyanate → (S)-Methyl 2-(5-(4-(3-(2-fluorophenyl)thioureido)phenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate

HRID 403882

반응식

HRID 403882 반응식
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[C:10]3[C:14](=[CH:15][CH:16]=2)[C:13](=[O:17])[N:12]([C@@H:18]([CH:23]([CH3:25])[CH3:24])[C:19]([O:21][CH3:22])=[O:20])[CH2:11]3)=[CH:4][CH:3]=1.[F:26][C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=1[N:33]=[C:34]=[S:35]>C1COCC1>[F:26][C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=1[NH:33][C:34](=[S:35])[NH:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[C:10]3[C:14](=[CH:15][CH:16]=2)[C:13](=[O:17])[N:12]([C@@H:18]([CH:23]([CH3:25])[CH3:24])[C:19]([O:21][CH3:22])=[O:20])[CH2:11]3)=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 975202-Fluorophenyl isothiocyanateHCID 131731499(S)-Methyl 2-(5-(4-aminophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate

생성물 1

HCID 131731509(S)-Methyl 2-(5-(4-(3-(2-fluorophenyl)thioureido)phenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

The compound of example 223 (0.150 g, 0.000443 mol) was taken in THF (3 mL) and 2-fluorophenyl isothiocyanate (0.074 g, 0.000448 mol) was added and stirred at room temperature for 8-10 h. The reaction mixture was concentrated and directly used for preparation of compound of example 257.

후처리

  1. concentrationThe reaction mixture was concentrated
  2. customdirectly used for preparation of compound of example 257

출처 및 근거

ORD 기록
ord-74667683940b4f4cb7e61ebb6a6d3d0c
출처 데이터셋
uspto-grants-2014_06
특허 번호
US08748426B2

연결된 노트

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