Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-(Trifluoromethyl)phenyl isothiocyanate → (S)-Methyl 3-methyl-2-(1-oxo-5-(4-(3-(2-(trifluoromethyl)phenyl)thioureido)phenyl)isoindolin-2-yl)butanoate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-(Trifluoromethyl)phenyl isothiocyanate | HCID 737162 | — |
| 반응물 | (S)-Methyl 2-(5-(4-aminophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate | HCID 131731499 | — |
| 반응물 | (S)-Methyl 2-(5-(4-(3-(2-fluorophenyl)thioureido)phenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate | HCID 131731509 | — |
| 생성물 | (S)-Methyl 3-methyl-2-(1-oxo-5-(4-(3-(2-(trifluoromethyl)phenyl)thioureido)phenyl)isoindolin-2-yl)butanoate | HCID 131731515 | — |
반응 단계
The compound of example 270 was prepared analogous to compound of example 256 by reaction of compound of example 223 with 2-trifluoromethyl phenyl isothiocyanate. The compound of example 270 was used directly without isolation, for the preparation of compound of example 271.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08748426B2 |
| 출처 데이터셋 | uspto-grants-2014_06 |
| ORD ID | ord-d1ae859955524f888709a20a69881c22 |
| 출처 메모 | uspto-grants-2014_06 |