Alanine methyl ester hydrochloride → (S)-Methyl 2-(6-bromo-1-oxoisoindolin-2-yl)propanoate

HRID 403936노트

반응식

HRID 403936 반응식
[Br:1][C:2]1[CH:10]=[C:9]2[C:5]([CH2:6][N:7]([C@H:12]([CH:17](C)C)[C:13]([O:15][CH3:16])=[O:14])[C:8]2=[O:11])=[CH:4][CH:3]=1.Cl.COC(=O)[C@H](C)N>>[Br:1][C:2]1[CH:10]=[C:9]2[C:5]([CH2:6][N:7]([C@@H:12]([CH3:17])[C:13]([O:15][CH3:16])=[O:14])[C:8]2=[O:11])=[CH:4][CH:3]=1

참가 물질

3

반응물 2

HCID 2733257Alanine methyl ester hydrochlorideHCID 131731530(R)-Methyl 2-(6-bromo-1-oxoisoindolin-2-yl)-3-methylbutanoate

생성물 1

HCID 125486231(S)-Methyl 2-(6-bromo-1-oxoisoindolin-2-yl)propanoate

실험 절차

The compound of example 335 was prepared analogous to compound of example 329 by reaction of the compound of example 328 and L-alanine methyl ester hydrochloride.

출처 및 근거

ORD 기록
ord-b0490ab00d83423f8000ab11a76cf2d4
출처 데이터셋
uspto-grants-2014_06
특허 번호
US08748426B2

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