4-Aminobutyric acid methyl ester hydrochloride → Methyl 4-(6-bromo-1-oxoisoindolin-2-yl)butanoate

HRID 403947노트

반응식

HRID 403947 반응식
[Br:1][C:2]1[CH:10]=[C:9]2[C:5]([CH2:6][N:7]([C@H:12]([CH:17]([CH3:19])C)C(OC)=O)[C:8]2=[O:11])=[CH:4][CH:3]=1.Cl.NCCC[C:25]([O:27][CH3:28])=[O:26]>>[Br:1][C:2]1[CH:10]=[C:9]2[C:5]([CH2:6][N:7]([CH2:12][CH2:17][CH2:19][C:25]([O:27][CH3:28])=[O:26])[C:8]2=[O:11])=[CH:4][CH:3]=1

참가 물질

3

반응물 2

HCID 27563834-Aminobutyric acid methyl ester hydrochlorideHCID 131731530(R)-Methyl 2-(6-bromo-1-oxoisoindolin-2-yl)-3-methylbutanoate

생성물 1

HCID 67307579Methyl 4-(6-bromo-1-oxoisoindolin-2-yl)butanoate

실험 절차

The compound of example 347 was prepared analogous to compound of example 329 by reaction of the compound of example 328 and methyl 4-aminobutanoate hydrochloride.

출처 및 근거

ORD 기록
ord-226e535caab547fd9b5996ad4057e6b2
출처 데이터셋
uspto-grants-2014_06
특허 번호
US08748426B2

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