Glycine methyl ester hydrochloride → Methyl 2-(5-bromo-1-oxoisoindolin-2-yl)acetate

HRID 403957

반응식

HRID 403957 반응식
[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[C:7](=[O:11])[N:6]([C@H:12](C(C)C)[C:13]([O:15][CH3:16])=[O:14])[CH2:5]2.BrC1C=CC(C(OC)=O)=C(CBr)C=1.Cl.COC(=O)CN>>[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[C:7](=[O:11])[N:6]([CH2:12][C:13]([O:15][CH3:16])=[O:14])[CH2:5]2

참가 물질

4

반응물 3

HCID 122755Glycine methyl ester hydrochlorideHCID 22031079Methyl 4-bromo-2-(bromomethyl)benzoateHCID 86673568(R)-Methyl 2-(5-bromo-1-oxoisoindolin-2-yl)-3-methylbutanoate

생성물 1

HCID 67306590Methyl 2-(5-bromo-1-oxoisoindolin-2-yl)acetate

실험 절차

The compound of example 362 was prepared analogous to compound of example 359 by reaction of the compound of example 358 and glycine methyl ester hydrochloride.

출처 및 근거

ORD 기록
ord-41224919cf1642cbaf6ef71f7d08f0a8
출처 데이터셋
uspto-grants-2014_06
특허 번호
US08748426B2

연결된 노트

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