Methyl 1-amino-1-cyclopentanecarboxylate, HCl → Methyl 1-(5-bromo-1-oxoisoindolin-2-yl)cyclopentanecarboxylate

HRID 403963

반응식

HRID 403963 반응식
[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[C:7](=[O:11])[N:6]([C@H:12]([CH:17]([CH3:19])C)[C:13]([O:15][CH3:16])=[O:14])[CH2:5]2.Br[C:21]1C=CC(C(OC)=O)=C(CBr)[CH:22]=1.Cl.NC1(C(OC)=O)CCCC1>>[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[C:7](=[O:11])[N:6]([C:12]1([C:13]([O:15][CH3:16])=[O:14])[CH2:17][CH2:19][CH2:22][CH2:21]1)[CH2:5]2

참가 물질

4

반응물 3

HCID 11513856Methyl 1-amino-1-cyclopentanecarboxylate, HClHCID 22031079Methyl 4-bromo-2-(bromomethyl)benzoateHCID 86673568(R)-Methyl 2-(5-bromo-1-oxoisoindolin-2-yl)-3-methylbutanoate

생성물 1

HCID 67313405Methyl 1-(5-bromo-1-oxoisoindolin-2-yl)cyclopentanecarboxylate

실험 절차

The compound of example 368 was prepared analogous to compound of example 359 by reaction of the compound of example 358 and methyl 1-aminocyclopentanecarboxylate hydrochloride.

출처 및 근거

ORD 기록
ord-72438040eda84a99b74ca38dfe17adf2
출처 데이터셋
uspto-grants-2014_06
특허 번호
US08748426B2

연결된 노트

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