4-Aminobutyric acid methyl ester hydrochloride → Methyl 4-(5-bromo-1-oxoisoindolin-2-yl)butanoate

HRID 403969

반응식

HRID 403969 반응식
[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[C:7](=[O:11])[N:6]([C@H:12]([CH:17]([CH3:19])C)C(OC)=O)[CH2:5]2.BrC1C=CC([C:25]([O:27][CH3:28])=[O:26])=C(CBr)C=1.Cl.NCCCC(OC)=O>>[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[C:7](=[O:11])[N:6]([CH2:12][CH2:17][CH2:19][C:25]([O:27][CH3:28])=[O:26])[CH2:5]2

참가 물질

4

반응물 3

HCID 27563834-Aminobutyric acid methyl ester hydrochlorideHCID 22031079Methyl 4-bromo-2-(bromomethyl)benzoateHCID 86673568(R)-Methyl 2-(5-bromo-1-oxoisoindolin-2-yl)-3-methylbutanoate

생성물 1

HCID 67306400Methyl 4-(5-bromo-1-oxoisoindolin-2-yl)butanoate

실험 절차

The compound of example 374 was prepared analogous to compound of example 359 by reaction of the compound of example 358 and methyl 4-aminobutanoate hydrochloride.

출처 및 근거

ORD 기록
ord-96c4f0921aab4edcba3bc6b0639d2c43
출처 데이터셋
uspto-grants-2014_06
특허 번호
US08748426B2

연결된 노트

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