Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Bromo-5-nitrobenzotrifluoride → (S)-Methyl 3-methyl-2-(6-(4-nitro-2-(trifluoromethyl)phenyl)-1-oxoisoindolin-2-yl)butanoate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Bromo-5-nitrobenzotrifluoride | HCID 136198 | — |
| 반응물 | (S)-Methyl 3-methyl-2-(1-oxo-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isoindolin-2-yl)butanoate | HCID 123866646 | — |
| 반응물 | (S)-Methyl 3-methyl-2-(6-(5-nitropyridin-2-yl)-1-oxoisoindolin-2-yl)butanoate | HCID 131731547 | — |
| 촉매 | Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+) | HCID 178418228 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | (S)-Methyl 3-methyl-2-(6-(4-nitro-2-(trifluoromethyl)phenyl)-1-oxoisoindolin-2-yl)butanoate | HCID 131731555 | 85% |
반응 단계
The compound of example 413 was prepared analogous to the compound of example 391 by reaction of the compound of example 390, 1-bromo-4-nitro-2-(trifluoromethyl)benzene and Pd(dppf)Cl2: CH2Cl2.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08748426B2 |
| 출처 데이터셋 | uspto-grants-2014_06 |
| ORD ID | ord-b122e9793f8247198e3c59a167f592bd |
| 출처 메모 | uspto-grants-2014_06 |