Methyl 3-aminocyclohexane-1-carboxylate hydrochloride → Methyl 3-(6-(4-nitrophenyl)-1-oxoisoindolin-2-yl)cyclohexanecarboxylate

HRID 404055

반응식

HRID 404055 반응식
CC(C)[C@H]([N:8]1[CH2:16][C:15]2[C:10](=[CH:11][C:12]([C:17]3[CH:22]=[CH:21][C:20]([N+:23]([O-:25])=[O:24])=[CH:19][CH:18]=3)=[CH:13][CH:14]=2)[C:9]1=[O:26])C(OC)=O.BrC[C:30]1[CH:35]=[CH:34][C:33](C2C=CC([N+]([O-])=O)=CC=2)=[CH:32][C:31]=1[C:45]([O:47][CH3:48])=[O:46].Cl.NC1CCCC(C(OC)=O)C1>>[N+:23]([C:20]1[CH:21]=[CH:22][C:17]([C:12]2[CH:11]=[C:10]3[C:15]([CH2:16][N:8]([CH:35]4[CH2:34][CH2:33][CH2:32][CH:31]([C:45]([O:47][CH3:48])=[O:46])[CH2:30]4)[C:9]3=[O:26])=[CH:14][CH:13]=2)=[CH:18][CH:19]=1)([O-:25])=[O:24]

참가 물질

4

반응물 3

HCID 13216967Methyl 3-aminocyclohexane-1-carboxylate hydrochlorideHCID 67306641Methyl 4-(bromomethyl)-4'-nitrobiphenyl-3-carboxylateHCID 131731440(S)-Methyl 3-methyl-2-(6-(4-nitrophenyl)-1-oxoisoindolin-2-yl)butanoate

생성물 1

HCID 67312960Methyl 3-(6-(4-nitrophenyl)-1-oxoisoindolin-2-yl)cyclohexanecarboxylate수율 59%

실험 절차

The compound of example 542 was prepared analogous to compound of example 5 by reaction of compound of example 4 with methyl 3-aminocyclohexanecarboxylate hydrochloride.

출처 및 근거

ORD 기록
ord-74903dbeffbf40d1b29cd5eab613844d
출처 데이터셋
uspto-grants-2014_06
특허 번호
US08748426B2

연결된 노트

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